Anxiety symptoms in adults
Evidence basis: randomised trials
Mindfulness meditation produces small to moderate reductions in anxiety symptoms compared with no intervention, but the advantage is not statistically significant against active controls.
Population: Adults across mixed clinical and non-clinical settings: 47 randomised trials with 3,515 participants in the meditation-programmes meta-analysis; 142 non-overlapping samples with 12,005 participants with psychiatric disorders in the clinical meta-analysis; 136 randomised trials with 11,605 participants in non-clinical settings, 77% women, aged 18 to 73 years, in 29 countries.
Research details
Summary
Mindfulness meditation produces small to moderate reductions in anxiety symptoms compared with no intervention. In a meta-analysis of 47 randomised trials with 3,515 participants restricted to trials with active controls, mindfulness meditation programmes had moderate-strength evidence of improved anxiety (effect size 0.38, 95% CI 0.12 to 0.64 at 8 weeks and 0.22, 95% CI 0.02 to 0.43 at 3 to 6 months), and the authors found no evidence that meditation programmes were better than any active treatment such as drugs, exercise or other behavioural therapies. A meta-analysis of 136 randomised trials in non-clinical settings (11,605 participants) found a larger average improvement in anxiety than no intervention (SMD -0.56, 95% CI -0.80 to -0.33, 95% PI -1.19 to 0.06) but no statistically significant evidence of improvement over non-specific active controls and none over specific active controls. A meta-analysis of 142 samples of clinical populations found mindfulness-based interventions superior to no treatment (d 0.55), minimal treatment (d 0.37), non-specific active controls (d 0.35) and specific active controls (d 0.23), but not different from evidence-based treatments (d -0.004).
Why this certainty
Rated Moderate: three independent syntheses agree on direction and on statistical significance against no-intervention comparators; the advantage is not statistically significant against active controls, and the clinical-population meta-analysis found a graded pattern of effect sizes across comparator strength that is difficult to explain by bias alone. It is not rated Strong because the effect against active controls is not demonstrated, the meta-analysis with the strictest inclusion criteria graded its anxiety evidence as moderate, all trials in the non-clinical review were at high risk of bias, prediction intervals cross zero, and no review isolates self-guided app practice for anxiety against an active comparator.
Limitations
The largest non-clinical review judged all included trials to be at high risk of bias, and effects on anxiety did not survive restriction to trial quality or comparison with active controls; its GRADE confidence was moderate to very low and prediction intervals for anxiety crossed zero. The meditation-programmes meta-analysis is limited by clinical heterogeneity, variable control types and heterogeneous interventions, and its 8-week anxiety estimate rests on data with a lower confidence bound of 0.12. Efficacy against no treatment is also the comparison most vulnerable to expectancy, attention and regression to the mean.
Effect estimate
Mindfulness meditation versus active control: effect size 0.38 (95% CI 0.12 to 0.64) at 8 weeks and 0.22 (95% CI 0.02 to 0.43) at 3 to 6 months (Goyal 2014). Mindfulness-based programmes versus no intervention in non-clinical settings: SMD -0.56 (95% CI -0.80 to -0.33; p < 0.001; 95% prediction interval -1.19 to 0.06; 8 trials) (Galante 2021). Mindfulness-based interventions versus comparators in clinical populations: d 0.55 versus no treatment, 0.35 versus non-specific active controls, 0.23 versus specific active controls, -0.004 versus evidence-based treatments (Goldberg 2018). Mindfulness apps versus control: g 0.28 (95% CI 0.21 to 0.35; 48 comparisons, 6,082 participants) (Linardon 2024).
- Meditation programs for psychological stress and well-being: a systematic review and meta-analysis
- Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A systematic review and meta-analysis of randomised controlled trials
- Mindfulness-based interventions for psychiatric disorders: A systematic review and meta-analysis
- The efficacy of mindfulness apps on symptoms of depression and anxiety: An updated meta-analysis of randomized controlled trials


