Cardiovascular disease, stroke and all-cause mortality (observational)
Evidence basis: observational studies (association, not proof of cause)
Pooled cohorts link higher legume intake to slightly lower all-cause mortality and stroke, but not to cardiovascular, coronary or cancer mortality, and one cohort found higher cardiovascular mortality.
Population: Adults in prospective cohort studies: 1,141,793 participants and 93,373 deaths in the largest dose-response meta-analysis, 2,081,432 participants across 31 cohorts in the systematic review, 7,216 older Mediterranean adults at high cardiovascular risk in PREDIMED, and 807,785 adults with up to 42,473 incident diabetes cases across 27 cohorts.
Research details
Summary
A dose-response meta-analysis of 32 cohorts covering 1,141,793 participants and 93,373 deaths found that higher legume intake was associated with lower all-cause mortality (HR 0.94, 95% CI 0.91 to 0.98) and lower stroke mortality (HR 0.91, 95% CI 0.84 to 0.99), with a 6% lower risk of all-cause mortality per 50 g a day (HR 0.94, 95% CI 0.89 to 0.99). There was no significant association for cardiovascular mortality (HR 0.99, 95% CI 0.91 to 1.09), coronary heart disease mortality (HR 0.93, 95% CI 0.78 to 1.09) or cancer mortality (HR 0.85, 95% CI 0.72 to 1.01), and the certainty of evidence was judged low to moderate. A systematic review and meta-analysis of 47 studies, including 31 cohorts with 2,081,432 participants, was suggestive of null associations for cardiovascular disease, coronary heart disease, stroke and type 2 diabetes, and graded the overall evidence as limited with no conclusion. In the PREDIMED cohort of 7,216 older adults at high cardiovascular risk, the highest tertile of total legume and dried bean intake was associated with higher cardiovascular mortality (HR 1.52, 95% CI 1.02 to 2.89 and HR 2.23, 95% CI 1.32 to 3.78 respectively), while higher total legume and lentil intake was associated with lower cancer mortality (HR 0.51, 95% CI 0.31 to 0.84 and HR 0.63, 95% CI 0.40 to 0.98). A federated meta-analysis of 27 cohorts found a weak positive association between total legume intake and incident type 2 diabetes (IRR 1.02, 95% CI 1.01 to 1.04 per 20 g a day) with no association for pulses or soy. The largest cohort analysis of the combined exposure, 135,335 adults in 18 countries, found that higher total fruit, vegetable and legume intake was associated with a hazard ratio of 0.81 (95% CI 0.68 to 0.96) for total mortality, with the lowest hazard at three to four servings a day; because that exposure is combined, it cannot be attributed to legumes alone, although legume intake examined separately was inversely associated with non-cardiovascular and total mortality in the fully adjusted models.
Why this certainty
Rated Limited. The meta-analyses are large and the direction of the all-cause mortality association is consistent, but the effect is small, the exposure is uniformly low across cohorts, and the evidence was graded low to moderate by the review that produced it and limited with no conclusion by the systematic review written for national nutrition recommendations. Certainty is not higher because there is no randomised evidence for any disease endpoint and the largest Mediterranean cohort found the opposite direction for cardiovascular mortality. It is not lower because several independent cohorts and pooled analyses agree on the all-cause mortality direction.
Limitations
Legume intake was generally low in these populations, which limits the range over which any dose-response can be estimated and makes the highest category a modest absolute intake. Diet was self-reported by food frequency questionnaire, usually measured once at baseline, and the review authors note a high degree of heterogeneity for most outcomes. The PREDIMED finding of higher cardiovascular mortality in the highest legume tertile runs against the rest of the literature and is plausibly explained by residual confounding or ill health, but it has not been reconciled. The weak positive diabetes association was concentrated in European cohorts and the authors suggest it may reflect the foods eaten alongside legumes rather than the legumes themselves. Randomised trials of cardiovascular events or death do not exist for this exposure.
Effect estimate
All-cause mortality HR 0.94 (95% CI 0.91 to 0.98) for highest versus lowest legume intake, and HR 0.94 (95% CI 0.89 to 0.99) per 50 g/day increment, across 32 cohorts with 1,141,793 participants.
- Legume Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies.
- Legume consumption in adults and risk of cardiovascular disease and type 2 diabetes: a systematic review and meta-analysis.
- Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study.
- Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions.
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study.

