Blood pressure in people with hypertension
Evidence basis: randomised trials
Flaxseed trials suggest lower blood pressure in hypertension, with substantial uncertainty.
Population: People with hypertension in five trials; the milled-flaxseed trial enrolled 110 patients with peripheral artery disease.
Research details
Summary
A 2024 meta-analysis of five randomized trials estimated a systolic reduction of 8.64 mmHg (95% CI 1.87 to 15.41 lower) and a diastolic reduction of 4.87 mmHg (95% CI 1.37 to 8.37 lower). In a six-month trial, 110 patients with peripheral artery disease received foods containing 30 g/day of milled flaxseed or placebo; benefit was selective for hypertensive patients. The pooled result covers flaxseed interventions and should not be treated as an identical ground-seed protocol in every trial.
Why this certainty
Limited certainty reflects randomized comparisons but few trials, heterogeneous protocols and wide confidence intervals. A targeted adjunct is more defensible than a general health or disease-prevention claim.
Limitations
Five trials are a small evidence base, and the full review reports high heterogeneity between studies. Formulations, participants and duration differ. Blood-pressure changes do not establish fewer cardiovascular events, and effects in normotensive people are not established.
Effect estimate
Systolic BP: -8.64 mmHg (95% CI -15.41 to -1.87) in five hypertension trials.
